Great Elders are the oldest and likely the wisest of the Elder Race. Most of them, if not all of them, helped in raising Danu Talis from the seabed using elemental magic. Some of the Elders and Great Elders in the Nicholas Flamel Series include
- Benzaiten- The Japanese goddess of flowing rivers, waters, music, art, and serpents.
- Thoth- The Egyptian god of knowledge and magic, along with Isis
- Nereus- A Greek god of the sea and the father of the Nereids.
- Typhon - Father of all monsters. From Greek mythology.
- Bastet - "I helped tear this island off the seabed. Along with your father, I ruled Danu Talis for millennia. I will not see it destroyed because of your brother's stupidity." (The Warlock, by Michael Scott)